Percutaneous kyphoplasty plus anti-osteoporosis drug for the treatment of acute osteoporotic vertebral compression fractures

doi:10.3969/j.issn.2095-4344.2014.39.006

Abstract

Abstract:

BACKGROUND: Percutaneous kyphoplasty for the treatment of vertebral compression fractures has gained good clinical results and it is characterized as small trauma, less bleeding and very low rate of complications. The vast majority of elderly patients can tolerate it, but this method cannot prevent fracture replase in the elderly.
OBJECTIVE: To evaluate clinical outcomes of percutaneous kyphoplasty combined with anti-osteoporosis drug for the treatment of acute osteoporotic vertebral compression fractures
METHODS: According to strict inclusion and exclusion criteria, 137 patients, including 26 males and 111 females, mean age of (75.55±6.96) years, with a total of 198 acute osteoporotic vertebral compression fractures treated by kyphoplasty that involves injection of polymethyl methacrylate cement under radiologic control into a treated vertebral body were conducted in this study. All patients were asked to take anti-osteoporosis drugs for 3 post-treatment months. The primary outcomes were visual analogue scale, ertebral restoring rate, Oswestry disability index, Cobb angle at different time (pre-operation, 1 week and 3 months after operation). In addition, the rate of complications and the replase rate of vertebral compression fractures after operation were recorded.
RESULTS AND CONCLUSION: There were significant differences in the mean visual analog scale scores, vertebral restoring rate, Oswestry disability index, Cobb angle at pre-procedure and post-procedure (at 1 week and 3 months) (P < 0.001). In addition, the rate of postoperative complications was 0.7% and there were no vertebral compression fractures during 3-month follow-up period. Our study suggests that percutaneous kyphoplasty combined with anti-osteoporosis drug for the treatment of acute osteoporotic vertebral compression fractures can gain good clinical results.

中国组织工程研究杂志出版内容重点：生物材料；骨生物材料; 口腔生物材料; 纳米材料; 缓释材料; 材料相容性；组织工程

全文链接：

Key words: methylmethacrylates, vertebroplasty, osteoporotic fractures

CLC Number:

R318

Yang Liu-zhu, Chen Zhong, Yan Xin-ping, Xu Zun-ying, Tan Wei. Percutaneous kyphoplasty plus anti-osteoporosis drug for the treatment of acute osteoporotic vertebral compression fractures[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(39): 6265-6270.

Figures/Tables 3

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